Microbial exposures that establish immunoregulation are compatible with targeted hygiene

It is often suggested that hygiene not compatible with the microbial exposures are necessary for establishment of immune system in early life. However, when we analyze modern humans context human evolution and history, it becomes evident whereas children need exposure to microbiotas their mothers, other family members, natural environment, unnatural microbiota home less relevant. In addition, any benefits infections childhood within household setting at least partly replaced by recently revealed nonspecific effects vaccines. This article shows how targeting practices key risk moments sites can maximize protection against infection while minimizing impact on essential exposures. Moreover, this must aim reduce direct cleaning agents because those probably exert TH2-adjuvant trigger allergic responses normally innocuous antigens. Finally, halt flow publications scientific literature media blame increases immunoregulatory disorders. 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